Search results for " Creatine kinase"

showing 10 items of 13 documents

Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real‐life setting: the PROSISA Study

2021

Aim: Statin-associated muscle symptoms (SAMS) are a major determinant of poor treatment adherence and/or discontinuation, but a definitive diagnosis of SAMS is challenging. The PROSISA study was an observational retrospective study aimed to assess the prevalence of reported SAMS in a cohort of dyslipidaemic patients. Methods: Demographic/anamnestic data, biochemical values and occurrence of SAMS were collected by 23 Italian Lipid Clinics. Adjusted logistic regression was performed to estimate odds ratio (OR) and 95% confidence intervals for association between probability of reporting SAMS and several factors. Results: Analyses were carried out on 16 717 statin-treated patients (mean ± SD, …

0301 basic medicineMalemedicine.medical_specialtySettore MED/09 - Medicina Internaadverse effects; myopathy; statin-associated muscle symptoms; statinsstatin-associated muscle symptomsadverse effects; myopathy; statin-associated muscle symptoms; statins.030204 cardiovascular system & hematologystatinsMedication Adherence03 medical and health sciences0302 clinical medicineMuscular DiseasesInternal medicineadverse effectInternal MedicinemedicinePrevalencestatins.Humansstatin‐associated muscle symptomsAdverse effectDechallengeadverse effects; myopathy; statin-associated muscle symptoms; statins; Creatine Kinase; Dyslipidemias; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Italy; Male; Medication Adherence; Middle Aged; Muscular Diseases; Prevalence; Retrospective StudiesCreatine KinaseDyslipidemiasRetrospective Studiesbusiness.industryRetrospective cohort studyOdds ratioOriginal ArticlesMiddle AgedConfidence intervalDiscontinuation030104 developmental biologyItalyConcomitantCohortadverse effectsOriginal ArticleFemaleHydroxymethylglutaryl-CoA Reductase Inhibitorsbusinessstatin-associated muscle symptommyopathyJournal of Internal Medicine
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Influence of middle-distance running on muscular micro RNAs

2018

A specific subset of micro RNAs (miRs), including miR-133 and miR-206, is specifically expressed in muscle tissue, so that they are currently defined as muscular miRs (myomiRs). To further elucidate the role of myomiRs in muscle biology, we measured miR-133a and miR-206 in plasma of 28 middle-age recreational athletes. The study population consisted of 28 middle aged, recreation athletes (11 women and 17 men; mean age, 46 years) who completed a 21.1 km, half-marathon. The plasma concentration of miR-133a and miR-206, the serum concentration of creatine kinase (CK) and high-sensitivity (HS) cardiac troponin T (cTnT), as well as capillary lactate, were measured before and immediately after th…

0301 basic medicineMuscle tissueMalemedicine.medical_specialtyClinical BiochemistryRunning03 medical and health sciencesTroponin complexDistance runningTroponin TInternal medicinemedicineHumansLactic AcidMuscle SkeletalCreatine KinasemiRNAProlonged exercisebiologyepigeneticsexercisemicroRNAepigenetics; exercise; microRNA; miRNA; Running; sport; Athletes; Creatine Kinase; Female; Gene Expression Regulation; Humans; Lactic Acid; Male; MicroRNAs; Middle Aged; Multivariate Analysis; Muscle Skeletal; Physical Endurance; Running; Troponin TGeneral MedicineSkeletalrunning; epigenetics; exercise; miRNA; microRNA; sportMiddle AgedRunning timeMicroRNAs030104 developmental biologyEndocrinologymedicine.anatomical_structureGene Expression RegulationBiological significanceAthletesMultivariate Analysisbiology.proteinPhysical EndurancePopulation studyMuscleCreatine kinaseFemalesport
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Training volume, androgen use and serum creatine kinase activity.

1989

Serum creatine kinase (CK) activities were investigated in elite male strength athletes (n = 20) during normal weight training and bodybuilding training (one training session per day), during high volume strength training (two sessions per day) and during strength training (one session per day) with the use of high dose synthetic androgens (five athletes in each subgroup). The findings demonstrated that the increase in serum CK was highest in the subgroup using androgens. These results suggest that strength training with the use of androgenic steroids leads to higher serum CK activities than normal strength training.

AdultMalemedicine.medical_specialtySynthetic androgensStrength trainingmedicine.drug_classeducationPhysical Therapy Sports Therapy and RehabilitationAnabolic AgentsInternal medicineMedicineHumansOrthopedics and Sports MedicineCreatine KinaseExercisePhysical Education and Trainingbiologybusiness.industryAthletesAndrogenic steroidsGeneral MedicineAndrogenbiology.organism_classificationEndocrinologyNormal weightbiology.proteinSerum creatine kinaseCreatine kinasebusinessResearch Article
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SERUM CREATINE KINASE LEVEL IN AMYOTROPHIC LATERAL SCLEROSIS: A USEFUL DIAGNOSTIC AID?

2008

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CK - ALSSettore MED/26 - NeurologiaSERUM CREATINE KINASE AMYOTROPHIC LATERAL SCLEROSIS
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Oxidative inactivation of mitochondrial creatine kinase: Differential sensitivity of isoforms

2010

Gene isoformBiochemistrybiologyChemistryMitochondrial Creatine KinaseBiophysicsbiology.proteinCreatine kinaseCell BiologySensitivity (control systems)Oxidative phosphorylationBiochemistryBiochimica et Biophysica Acta (BBA) - Bioenergetics
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Acute polymyositis during treatment of acute hepatitis C with pegylated interferon alpha-2b.

2005

Hepatitis C virus is not cleared after primary infection in 50-85% of subjects exposed to hepatitis C virus. Anti-viral treatment during the early phase of infection significantly enhances the likelihood of a sustained clearance of hepatitis C virus. Although, a variety of autoimmune-related side effects have been observed during interferon therapy for chronic hepatitis, immuno-mediated adverse reactions have not been reported during treatment of acute hepatitis C. We describe the case of a patient who developed acute hepatitis C virus infection and, while receiving pegylated interferon alpha-2b monotherapy, developed a severe polymyositis. This case illustrates the potential risk of autoim…

MaleHepatitis C virusHepacivirusAcute hepatitis CAlpha interferonAutoimmunityHepacivirusInterferon alpha-2medicine.disease_causeIFNPolymyositisPolyethylene GlycolAntiviral AgentsVirusPolyethylene GlycolsPegylated interferonInterferonmedicineHumansDrug CarrierCreatine KinasePolymyositiAntiviral AgentDrug CarriersHepaciviruHepatologybiologybusiness.industryGastroenterologyInterferon-alphaHepatitis CRecombinant ProteinMiddle Agedmedicine.diseasebiology.organism_classificationHepatitis CRecombinant ProteinsAcute hepatitis C; Hepatitis C virus; IFN; Polymyositis; Acute Disease; Antiviral Agents; Autoimmunity; Creatine Kinase; Drug Carriers; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Male; Middle Aged; Polyethylene Glycols; Polymyositis; RNA Viral; Recombinant Proteins; GastroenterologyPolymyositisImmunologyAcute DiseaseRNA ViralbusinessHepatitis C virumedicine.drugHumanDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
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Can exercise-induced muscle damage be related to changes in skin temperature?

2018

Measurement of skin temperature using infrared thermography has become popular in sports, and has been proposed as an indicator of exercise-induced muscle damage after exercise. However, the relationship between skin temperature and exercise-induced muscle damage is still unclear. Here we set out to investigate the relationship between skin temperature and exercise-induced muscle damage.Twenty untrained participants completed a protocol of exercise for calf muscles. Before and after exercise blood samples were collected to determine creatine kinase and acetylcholinesterase activity. Thermal images were recorded from the exercised muscles to determine skin temperature. Delayed onset muscle s…

Malemedicine.medical_specialtyPhysiologyInfrared RaysBiomedical EngineeringBiophysicsMuscle damageIncreased creatine kinase03 medical and health scienceschemistry.chemical_compoundYoung Adult0302 clinical medicinePhysiology (medical)Internal medicineDelayed onset muscle sorenessMedicineHumansExercise physiologyMuscle SkeletalCreatine KinaseExercisebiologybusiness.industrySkin temperature030229 sport sciencesMyalgiaAcetylcholinesteraseEndocrinologychemistryLower ExtremityThermographybiology.proteinAcetylcholinesteraseCreatine kinaseTime momentmedicine.symptombusinessSkin Temperature030217 neurology & neurosurgeryPhysiological measurement
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Preferential Type II Muscle Fiber Damage From Plyometric Exercise

2012

Context: Plyometric training has been successfully used in different sporting contexts. Studies that investigated the effect of plyometric training on muscle morphology are limited, and results are controversial with regard to which muscle fiber type is mainly affected. Objective: To analyze the skeletal muscle structural and ultrastructural change induced by an acute bout of plyometric exercise to determine which type of muscle fibers is predominantly damaged. Design: Descriptive laboratory study. Setting: Research laboratory. Patients or Other Participants: Eight healthy, untrained individuals (age = 22 ± 1 years, height = 179.2 ± 6.4 cm, weight = 78.9 ± 5.9 kg). Intervention(s): Partici…

Reflex Stretchmedicine.medical_specialtyPhysical Therapy Sports Therapy and RehabilitationContext (language use)Plyometric ExerciseSarcomereYoung AdultHumansPlyometricsMedicineOrthopedics and Sports MedicineExercise physiologyMuscle SkeletalCreatine KinaseExerciseOriginal ResearchbiologySettore BIO/16 - Anatomia Umanabusiness.industrySkeletal muscleGeneral Medicinemedicine.anatomical_structureMuscle Fibers Fast-Twitchbiology.proteinPhysical therapyCreatine kinasemedicine.symptombusinessType II Muscle Fibereccentric exercise sarcomere Z-disk streaming electron transmission microscopy creatine kinase dystrophinMuscle ContractionMuscle contractionJournal of Athletic Training
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Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.

2009

Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C…

aged; analysis of variance; antigens; blood; blood cell count; body mass index; bone marrow transplantation; case-control studies; cd; chronic obstructive; chronic obstructive pulmonary disease; colony-forming units assay; creatine kinase; cytokines; endothelial cells; enzyme-linked immunosorbent assay; fat-free mass; female; humans; intercellular signaling peptides and proteins; lactate dehydrogenases; low-bmi copd; male; metabolism; methods; middle aged; normal-bmi copd; physiology; physiopathology/surgery; pulmonary disease; severity of illness index; statistics as topicMalePathologyPhysiologyStatistics as TopicCD34GastroenterologySeverity of Illness IndexBody Mass IndexPulmonary Disease Chronic Obstructiveantigenslow-bmi copdnormal-bmi copdCreatine Kinasepulmonary diseaseBone Marrow TransplantationCOPDchronic obstructiveGeneral NeuroscienceRespiratory diseaseMiddle Agedcdfat-free massHaematopoiesismedicine.anatomical_structurephysiopathology/surgeryCytokinesIntercellular Signaling Peptides and ProteinsFemalePulmonary and Respiratory Medicinemedicine.medical_specialtyEnzyme-Linked Immunosorbent Assaymacromolecular substancesSettore MED/10 - Malattie Dell'Apparato Respiratoriochronic obstructive pulmonary diseasemethodsColony-Forming Units AssayChronic obstructive pulmonary disease low-BMI COPD normal-BMI COPD fat-free massbloodAntigens CDInternal medicineSeverity of illnessmedicineHumansProgenitor cellLactate DehydrogenasesAgedAnalysis of Variancebusiness.industryCase-control studyEndothelial Cellsmedicine.diseaseBlood Cell CountCase-Control StudiesBone marrowbusinessmetabolismRespiratory physiologyneurobiology
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The effects of rapid weight loss on skeletal muscle in judo athletes

2020

Abstract Objective To observe the effect of rapid weight loss (RWL) methods over 3 days on muscle damage in judokas. Methods Eighteen judokas participated in this crossover study, meaning that judo athletes were subjected to exercise-only phase (4 days) and RWL phase (3 days). Subjects were tested for myoglobin, creatine kinase, aldolase, hemoglobin, and hematocrit values on seven consecutive days. These biomarkers served as indicators of acute muscle damage. Results During the exercise-only phase, no significant changes were observed. Myoglobin (Mb) (p < 0.001), creatine kinase (CK) (p < 0.001) and aldolase (ALD) (p < 0.001) significantly increased only during the RWL phase, as we…

medicine.medical_specialtyAldolase; Combat sports; Creatine kinase; Muscle damage; Myoglobin; Weight reductionCombat sportsWeight reductionlcsh:MedicineAldolase Combat sports Creatine kinase Muscle damage Myoglobin Weight reduction030204 cardiovascular system & hematologyHematocritGeneral Biochemistry Genetics and Molecular Biology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineMuscle damageWeight lossInternal medicineWeight LossmedicineAldolaseHumansCreatine kinaseMuscle SkeletalCross-Over Studiesmedicine.diagnostic_testbiologybusiness.industryAthletesMyoglobinResearchlcsh:RSkeletal muscle030229 sport sciencesGeneral Medicinebiology.organism_classificationCrossover studyEndocrinologymedicine.anatomical_structureMyoglobinchemistryAthletesbiology.proteinCreatine kinaseHemoglobinmedicine.symptombusinessSettore M-EDF/01 - Metodi E Didattiche Delle Attivita' MotorieMartial Arts
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